Interaction of propofol with voltage-gated human Kv1.5 channel through specific amino acids within the pore region.

@article{Kojima2015InteractionOP,
  title={Interaction of propofol with voltage-gated human Kv1.5 channel through specific amino acids within the pore region.},
  author={Akiko Kojima and Yuki Ito and Wen-shu Ding and Hirotoshi Kitagawa and Hiroshi Matsuura},
  journal={European journal of pharmacology},
  year={2015},
  volume={764},
  pages={
          622-32
        }
}
The intravenous anesthetic propofol affects the function of a diversity of ligand-gated and voltage-gated ion channels. However, there is little information as to whether propofol directly interacts with voltage-gated ion channel proteins to modulate their functions. The Kv1.5 channel is activated by membrane depolarization during action potentials and contributes to atrial repolarization in the human heart. This study was undertaken to examine the effect of propofol on voltage-gated human Kv1… CONTINUE READING
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SHOWING 1-10 OF 45 REFERENCES

Mutational analysis of molecular requirements for the actions of general anaesthetics at the -aminobutyric acidA receptor subtype, 122

R. Siegwart, K. Krähenbühl, S. Lambert, U. Rudolph
  • BMC Pharmacol
  • 2003
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Molecular targets underlying general anaesthesia.

  • British journal of pharmacology
  • 2006
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Emerging molecular mechanisms of general anesthetic action.

  • Trends in pharmacological sciences
  • 2005
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

Molecular and neuronal substrates for general anaesthetics

  • Nature Reviews Neuroscience
  • 2004
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

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