Interaction of primary amphipathic cell-penetrating peptides with phospholipid-supported monolayers.

@article{Plnat2004InteractionOP,
  title={Interaction of primary amphipathic cell-penetrating peptides with phospholipid-supported monolayers.},
  author={Thomas Pl{\'e}nat and S{\'e}bastien Deshayes and Sylvie Boichot and Pierre Emmanuel Milhiet and Richard B Cole and Fr{\'e}d{\'e}ric Heitz and C Christian Le Grimellec},
  journal={Langmuir : the ACS journal of surfaces and colloids},
  year={2004},
  volume={20 21},
  pages={9255-61}
}
The mesoscopic organization adopted by two primary amphipathic peptides, P(beta) and P(alpha), in Langmuir-Blodgett (LB) films made of either the pure peptide or peptide-phospholipid mixtures was examined by atomic force microscopy. P(beta), a potent cell-penetrating peptide (CPP), and P(alpha) mainly differ by their conformational states, predominantly a beta-sheet for P(beta) and an alpha-helix for P(alpha), as determined by Fourier transform infrared spectroscopy. LB films of pure peptide… CONTINUE READING

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