Corpus ID: 38917963

Interaction of preservatives with macromolecules: Part I--Natural hydrocolloids.

  title={Interaction of preservatives with macromolecules: Part I--Natural hydrocolloids.},
  author={T. R. R. Kurup and L. S. C. Wan and Lai Wah Chan},
  journal={Pharmaceutica acta Helvetiae},
  volume={67 11},
Antibacterial activity of methyl-p-hydroxybenzoate against Ps. aeruginosa was evaluated in the presence of varying concentrations of acacia, tragacanth, sodium alginate, guar gum and carrageenin. All these hydrocolloids reduced the antibacterial activity to varying degrees. Tragacanth and guar gum inhibited the activity to a greater extent than acacia, sodium alginate and carrageenin. Hydrocolloids reduce the antibacterial activity of preservatives in two ways. Interaction of the preservative… Expand
7 Citations
Study of Interaction Effects of Polyacrylic Acid Polymers (Carbopol 940) on Antimicrobial Activity of Methyl Parahydroxybenzoate Against Some Gram‐negative, Gram‐positive Bacteria and Yeast
Cosmetic or pharmaceutical formulations containing hydrophilic polymers of natural or synthetic origin, may be more exposed to successful microbial contamination because of a polymer‐preservativeExpand
Interaction of p-hydroxybenzoic esters with beta-cyclodextrin.
Studies using 1H-NMR showed that the extent of interaction depended on how well the parabens could fit into the betaCD cavity, and further increase in the size of the alkyl group significantly enhanced the amount of interaction. Expand
Acacia nilotica (L.) Delile. (Fabaceae/Leguminosae)
Gum Arabic is reported clinically useful in cases of chronic renal disease, especially the End-Stage Renal Disease (ESRD) requiring renal dialysis; and, administration of gum Arabic is also reported to decrease TC and LDL-C in mild hypercholesterolemia. Expand
Letter to the Editor
J Clin Pharmacol 2008;48:123-124 123 T recently published article by Gonzalez et al reports the results of a study comparing the stability, efficacy, and adverse effect profile of an innovatorExpand