Corpus ID: 38917963

Interaction of preservatives with macromolecules: Part I--Natural hydrocolloids.

@article{Kurup1992InteractionOP,
  title={Interaction of preservatives with macromolecules: Part I--Natural hydrocolloids.},
  author={T. R. R. Kurup and L. S. C. Wan and Lai Wah Chan},
  journal={Pharmaceutica acta Helvetiae},
  year={1992},
  volume={67 11},
  pages={
          301-7
        }
}
Antibacterial activity of methyl-p-hydroxybenzoate against Ps. aeruginosa was evaluated in the presence of varying concentrations of acacia, tragacanth, sodium alginate, guar gum and carrageenin. All these hydrocolloids reduced the antibacterial activity to varying degrees. Tragacanth and guar gum inhibited the activity to a greater extent than acacia, sodium alginate and carrageenin. Hydrocolloids reduce the antibacterial activity of preservatives in two ways. Interaction of the preservative… Expand
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