Interaction of prenylcysteine methyl esters with the multidrug resistance transporter.

@article{Zhang1994InteractionOP,
  title={Interaction of prenylcysteine methyl esters with the multidrug resistance transporter.},
  author={Li Zhang and C W Sachs and Robert Fine and Patrick J. Casey},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 23},
  pages={15973-6}
}
The multidrug resistance transporter is an integral membrane protein, termed P-glycoprotein, which can function as an ATP-dependent drug efflux pump to reduce intracellular drug accumulation in treated cells. The physiologic function of this protein in normal cells, however, is not completely understood. We report here that prenylcysteine methyl esters, which represent the C-terminal structures of prenylated proteins, both stimulate the transporter's intrinsic ATPase activity and compete for… CONTINUE READING

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