Interaction of poly(ethylenimine)-DNA polyplexes with mitochondria: implications for a mechanism of cytotoxicity.

@article{Grandinetti2011InteractionOP,
  title={Interaction of poly(ethylenimine)-DNA polyplexes with mitochondria: implications for a mechanism of cytotoxicity.},
  author={Giovanna Grandinetti and Nilesh P Ingle and Theresa M Reineke},
  journal={Molecular pharmaceutics},
  year={2011},
  volume={8 5},
  pages={1709-19}
}
Poly(ethylenimine) (PEI) and PEI-based systems have been widely studied for use as nucleic acid delivery vehicles. However, many of these vehicles display high cytotoxicity, rendering them unfit for therapeutic use. By exploring the mechanisms that cause cytotoxicity, and through understanding structure-function relationships between polymers and intracellular interactions, nucleic acid delivery vehicles with precise intracellular properties can be tailored for specific function. Previous… CONTINUE READING
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