Interaction of poly(amidoamine) dendrimers with supported lipid bilayers and cells: hole formation and the relation to transport.

@article{Hong2004InteractionOP,
  title={Interaction of poly(amidoamine) dendrimers with supported lipid bilayers and cells: hole formation and the relation to transport.},
  author={Seungpyo Hong and Anna U. Bielinska and Almut Mecke and Balazs Keszler and James L Beals and Xiangyang Shi and Lajos P. Balogh and Bradford G. Orr and James R Baker and Mark M Banaszak Holl},
  journal={Bioconjugate chemistry},
  year={2004},
  volume={15 4},
  pages={
          774-82
        }
}
We have investigated poly(amidoamine) (PAMAM) dendrimer interactions with supported 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) lipid bilayers and KB and Rat2 cell membranes using atomic force microscopy (AFM), enzyme assays, flow cell cytometry, and fluorescence microscopy. Amine-terminated generation 7 (G7) PAMAM dendrimers (10-100 nM) were observed to form holes of 15-40 nm in diameter in aqueous, supported lipid bilayers. G5 amine-terminated dendrimers did not initiate hole formation… CONTINUE READING
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