Interaction of platinum complexes of thiazin and xanthene dyes with hyperthermia

Abstract

In an attempt to develop platinum-containing drugs for use with hyperthermia that would be relatively nontoxic at 37° C but would become very cytotoxic at 42° or 43° C, several nuclear dyes were complexed to the tetrachloroplatinum(II) dianion (PtCl4) at a ratio of 2:1. The cytotoxicity of PtCl4 complexes of three thiazin dyes (thionin, azure B, and… (More)
DOI: 10.1007/BF02897258

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