Interaction of plasma membrane fibronectin receptor with talin—a transmembrane linkage

  title={Interaction of plasma membrane fibronectin receptor with talin—a transmembrane linkage},
  author={A. Horwitz and K. Duggan and C. Buck and M. Beckerle and K. Burridge},
  • A. Horwitz, K. Duggan, +2 authors K. Burridge
  • Published 1986
  • Chemistry, Medicine
  • Nature
  • Many observations suggest the presence of transmembrane linkages between the cytoskeleton and the extracellular matrix. In fibroblasts both light and electron microscopic observations reveal a co-alignment between actin filaments at the cell surface and extracellular fibronectin1–3. These associations are seen at sites of cell matrix interaction, frequently along stress fibres and sometimes where these bundles of microfilaments terminate at adhesion plaques (focal contacts). Non-morphological… CONTINUE READING
    1,146 Citations
    Actin-membrane interaction in focal adhesions.
    • 124
    Role of Adhesion Molecule Cytoplasmic Domains in Mediating Interactions with the Cytoskeleton
    • F. Pavalko, C. Otey
    • Biology, Medicine
    • Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
    • 1994
    • 117
    Biochemical and structural properties of the integrin-associated cytoskeletal protein talin.
    • D. Critchley
    • Biology, Medicine
    • Annual review of biophysics
    • 2009
    • 234
    Fibronectin-cell interactions.
    • 87
    Interaction of the cytoskeleton with the plasma membrane
    • 30
    Regulation of platelet function by the cytoskeleton.
    • J. Fox
    • Chemistry, Medicine
    • Advances in experimental medicine and biology
    • 1993
    • 45


    Development of cell surface linkage complexes in cultured fibroblasts
    • 288
    • PDF
    An interaction between vinculin and talin
    • 400
    Relationships between fibronectin (LETS protein) and actin
    • 401
    A new protein of adhesion plaques and ruffling membranes
    • 383
    • PDF