Interaction of plasma membrane fibronectin receptor with talin—a transmembrane linkage

@article{Horwitz1986InteractionOP,
  title={Interaction of plasma membrane fibronectin receptor with talin—a transmembrane linkage},
  author={A. Horwitz and K. Duggan and C. Buck and M. Beckerle and K. Burridge},
  journal={Nature},
  year={1986},
  volume={320},
  pages={531-533}
}
  • A. Horwitz, K. Duggan, +2 authors K. Burridge
  • Published 1986
  • Chemistry, Medicine
  • Nature
  • Many observations suggest the presence of transmembrane linkages between the cytoskeleton and the extracellular matrix. In fibroblasts both light and electron microscopic observations reveal a co-alignment between actin filaments at the cell surface and extracellular fibronectin1–3. These associations are seen at sites of cell matrix interaction, frequently along stress fibres and sometimes where these bundles of microfilaments terminate at adhesion plaques (focal contacts). Non-morphological… CONTINUE READING
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