Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development

  title={Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development},
  author={Abdolrahman Shams Nateri and Bradley Spencer-Dene and Axel Behrens},
The proto-oncoprotein c-Jun is a component of the AP-1 transcription factor, the activity of which is augmented in many tumour types. An important mechanism in the stimulation of AP-1 function is amino-terminal phosphorylation of c-Jun by the c-Jun N-terminal kinases (JNKs). Phosphorylated c-Jun is biologically more active, partially because it acquires the ability to interact with binding partners. Here we show that phosphorylated c-Jun interacts with the HMG-box transcription factor TCF4 to… CONTINUE READING
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