Interaction of permeant and blocking ions in cloned inward-rectifier K+ channels.

@article{Oliver1998InteractionOP,
  title={Interaction of permeant and blocking ions in cloned inward-rectifier K+ channels.},
  author={Dominik Oliver and Harry S Hahn and Christoph Antz and Johann Peter Ruppersberg and Bernd Fakler},
  journal={Biophysical journal},
  year={1998},
  volume={74 5},
  pages={
          2318-26
        }
}
Blocking cloned inward-rectifier potassium (Kir) channels from the cytoplasmic side was analyzed with a rapid application system exchanging the intracellular solution on giant inside-out patches from Xenopus oocytes in <2 ms. Dependence of the pore-block on interaction of the blocking molecule with permeant and impermeant ions on either side of the membrane was investigated in Kir1.1 (ROMK1) channels blocked by ammonium derivatives and in Kir4.1 (BIR10) channels blocked by spermine. The… CONTINUE READING
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