Interaction of peptide antigens and class II major histocompatibility complex antigens

@article{Guillet1986InteractionOP,
  title={Interaction of peptide antigens and class II major histocompatibility complex antigens},
  author={Jean-Gerrard Guillet and Ming-Zong Lai and Thomas Briner and John Arthur Smith and Malcolm L. Gefter},
  journal={Nature},
  year={1986},
  volume={324},
  pages={260-262}
}
T lymphocytes require a foreign antigen to be presented on a cell surface in association with a self-transplantation antigen before they can recognize it effectively. This phenomenon is known as major histocompatibility complex (MHC) restriction1. It is not clear how an incalculably large number of foreign proteins form unique complexes with a very limited number of MHC molecules. We studied the recognition properties of T cells specific for a peptide derived from bacteriophage A cl protein… CONTINUE READING

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