Interaction of papillomaviruses with the cell surface.

  title={Interaction of papillomaviruses with the cell surface.},
  author={Richard B S Roden and Reinhard Kirnbauer and Alfred Bennett Jenson and Douglas R Lowy and John T. Schiller},
  journal={Journal of virology},
  volume={68 11},
To initiate an investigation of the initial step in papillomavirus infection, we have examined the interaction of bovine papillomavirus type 1 (BPV) virions with C127 cells by two assays, binding of radioiodinated BPV virions to cell monolayers and BPV-induced focal transformation. Under physiological conditions, the labeled virions bound to the cell surface in a dose-dependent manner within 1 h. Antibody studies indicated that the interaction was specific and related to infectivity: polyclonal… CONTINUE READING