Interaction of papaverine with micelles of surfactants with different charge studied by 1H-NMR.

Abstract

The interaction of the vasodilator drug papaverine (PAV) with micelles of surfactants with different charge of headgroups as well as the properties of PAV in D2O solution were studied by 1H-NMR. At pD values above 6.4 deprotonated PAV molecules tend to precipitate, the signals of the heterocycle protons of solubilized PAV molecules being shifted to high… (More)

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