Interaction of ozone and allergen challenges on bronchial responsiveness and inflammation in sensitised guinea pigs.

@article{Sun1997InteractionOO,
  title={Interaction of ozone and allergen challenges on bronchial responsiveness and inflammation in sensitised guinea pigs.},
  author={Jie Sun and Hiroshi Koto and Kian Fan Chung},
  journal={International archives of allergy and immunology},
  year={1997},
  volume={112 2},
  pages={191-5}
}
BACKGROUND Environmental pollutants such as ozone may interact with airway responses to allergen in sensitised individuals. METHODS We examined the effects of a single exposure to ozone (1 ppm for 1 h) on bronchial responsiveness to acetylcholine (ACh) aerosol 3 and 24 h after single ovalbumin (OA) challenge in OA-sensitised anaesthetised guinea pigs. Broncho-alveolar lavage (BAL) was performed and protein content and differential cell counts were determined. RESULTS Ozone increased… CONTINUE READING

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