Interaction of ostreolysin, a cytolytic protein from the edible mushroom Pleurotus ostreatus, with lipid membranes and modulation by lysophospholipids.

@article{Sepi2003InteractionOO,
  title={Interaction of ostreolysin, a cytolytic protein from the edible mushroom Pleurotus ostreatus, with lipid membranes and modulation by lysophospholipids.},
  author={Kristina Sep{\vc}i{\'c} and Sabina Berne and Cristina Potrich and Tom Turk and Peter Ma{\vc}ek and Gianfranco Menestrina},
  journal={European journal of biochemistry},
  year={2003},
  volume={270 6},
  pages={1199-210}
}
Ostreolysin is a 16-kDa cytolytic protein specifically expressed in primordia and fruiting bodies of the edible mushroom Pleurotus ostreatus. To understand its interaction with lipid membranes, we compared its effects on mammalian cells, on vesicles prepared with either pure lipids or total lipid extracts, and on dispersions of lysophospholipids or fatty acids. At nanomolar concentrations, the protein lysed human, bovine and sheep erythrocytes by a colloid-osmotic mechanism, compatible with the… CONTINUE READING

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