Interaction of oral antidiabetic drugs with hepatic uptake transporters: focus on organic anion transporting polypeptides and organic cation transporter 1.

@article{Bachmakov2008InteractionOO,
  title={Interaction of oral antidiabetic drugs with hepatic uptake transporters: focus on organic anion transporting polypeptides and organic cation transporter 1.},
  author={Iouri Bachmakov and Hartmut Glaeser and Martin F. Fromm and J. Frank Koenig},
  journal={Diabetes},
  year={2008},
  volume={57 6},
  pages={1463-9}
}
OBJECTIVE The uptake of drugs into hepatocytes is a key determinant for hepatic metabolism, intrahepatic action, their subsequent systemic plasma concentrations, and extrahepatic actions. In vitro and in vivo studies indicate that many drugs used for treatment of cardiovascular diseases (e.g., oral antidiabetic drugs, statins) are taken up into hepatocytes by distinct organic anion transporters (organic anion transporting polypeptides [OATPs]; gene symbol SLCO/SLC21) or organic cation… CONTINUE READING
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