Interaction of omeprazole, lansoprazole and pantoprazole with P-glycoprotein

@article{PauliMagnus2001InteractionOO,
  title={Interaction of omeprazole, lansoprazole and pantoprazole with P-glycoprotein},
  author={C. Pauli-Magnus and Sabine Rekersbrink and U. Klotz and M. Fromm},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2001},
  volume={364},
  pages={551-557}
}
  • C. Pauli-Magnus, Sabine Rekersbrink, +1 author M. Fromm
  • Published 2001
  • Chemistry, Medicine
  • Naunyn-Schmiedeberg's Archives of Pharmacology
  • Abstract. Proton pump inhibitors are a class of drugs which are widely prescribed for acid-related diseases. They are primarily metabolized by CYP2C19 and CYP3A4. It is unknown so far whether proton pump inhibitors are also substrates of the ATP-dependent efflux transporter P-glycoprotein. Moreover, it is not established whether proton pump inhibitors are also inhibitors of P-glycoprotein function. The aim of our study was therefore to characterize omeprazole, lansoprazole and pantoprazole as P… CONTINUE READING

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