Interaction of nucleolin with ribosomal RNA genes and its role in RNA polymerase I transcription

@inproceedings{Cong2012InteractionON,
  title={Interaction of nucleolin with ribosomal RNA genes and its role in RNA polymerase I transcription},
  author={Rong Cong and Sadhan Das and Iva Ugrinova and Sanjeev Kumar and Fabien Mongelard and Jiemin Wong and Philippe Bouvet},
  booktitle={Nucleic acids research},
  year={2012}
}
Nucleolin is a multi-functional nucleolar protein that is required for ribosomal RNA gene (rRNA) transcription in vivo, but the mechanism by which nucleolin modulates RNA polymerase I (RNAPI) transcription is not well understood. Nucleolin depletion results in an increase in the heterochromatin mark H3K9me2 and a decrease in H4K12Ac and H3K4me3 euchromatin histone marks in rRNA genes. ChIP-seq experiments identified an enrichment of nucleolin in the ribosomal DNA (rDNA) coding and promoter… CONTINUE READING
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