Interaction of nuclear proteins with an AP-1/CRE-like promoter sequence in the human TNF-alpha gene.

@article{Newell1994InteractionON,
  title={Interaction of nuclear proteins with an AP-1/CRE-like promoter sequence in the human TNF-alpha gene.},
  author={C L Newell and Albert B. Deisseroth and Gabriel L{\'o}pez-Berestein},
  journal={Journal of leukocyte biology},
  year={1994},
  volume={56 1},
  pages={27-35}
}
The tumor necrosis factor alpha (TNF-alpha) promoter contains an AP-1/CRE-like binding site, TGAGCTCA. AP-1 elements generally transduce signals involving protein kinase C; the CRE site mediates a cAMP response, involving protein kinase A. Thus, this element has the potential to receive signals through divergent signaling pathways. Nuclear protein binding studies using extracts from THP-1 monocytic cells treated with lipopolysaccharide (LPS), which stimulates, or dexamethasone (Dex) or… CONTINUE READING
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