Interaction of nitric oxide with ceruloplasmin lacking an EPR-detectable type 2 copper.

@article{Musci1991InteractionON,
  title={Interaction of nitric oxide with ceruloplasmin lacking an EPR-detectable type 2 copper.},
  author={Giovanni Musci and Stefania Di Marco and Maria Carmela Bonaccorsi di Patti and Lilia Calabrese},
  journal={Biochemistry},
  year={1991},
  volume={30 41},
  pages={9866-72}
}
Nitric oxide (NO) has previously been reported to modify the EPR spectrum of multicopper blue oxidases, disclosing a pure type 2 copper and inducing half-field transitions at g = 4. In the present work the reactivity of NO was reinvestigated with respect to ceruloplasmins having an apparently EPR-silent type 2 copper in their native state. The optical properties of NO-treated ceruloplasmin were independent of the initial redox state of the metal sites. Addition of NO caused the absorption at… CONTINUE READING