Interaction of nitric oxide and serotonin in aggressive behavior

  title={Interaction of nitric oxide and serotonin in aggressive behavior},
  author={S. Chiavegatto and R. Nelson},
  journal={Hormones and Behavior},
  • S. Chiavegatto, R. Nelson
  • Published 2003
  • Medicine, Biology
  • Hormones and Behavior
  • Nitric oxide (NO) modulates many behavioral and neuroendocrine responses. Genetic or pharmacological inhibition of the synthetic enzyme that produces NO in neurons evokes elevated and sustained aggression in male mice. Recently, the excessive aggressive and impulsive traits of neuronal NO synthase knockout (nNOS-/-) mice were shown to be caused by reductions in serotonin (5-HT) turnover and deficient 5-HT1A and 5-HT1B receptor function in brain regions regulating emotion. The consistently high… CONTINUE READING
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    Publications referenced by this paper.
    Brain serotonin dysfunction accounts for aggression in male mice lacking neuronal nitric oxide synthase.
    • 197
    • Open Access
    Reduced aggression in mice lacking the serotonin transporter
    • 236
    Inhibition of Neuronal Nitric Oxide Synthase Increases Aggressive Behavior in Mice
    • 102
    • Open Access
    Behavioural abnormalities in male mice lacking neuronal nitric oxide synthase
    • 568
    Elimination of Aggressive Behavior in Male Mice Lacking Endothelial Nitric Oxide Synthase
    • 108
    • Open Access
    Enhanced aggressive behavior in mice lacking 5-HT1B receptor.
    • 813
    Alcohol-heightened aggression in mice: attenuation by 5-HT1A receptor agonists
    • 105