Interaction of nitric oxide and serotonin in aggressive behavior.

  title={Interaction of nitric oxide and serotonin in aggressive behavior.},
  author={S Chiavegatto and Randy J Nelson},
  journal={Hormones and behavior},
  volume={44 3},
Nitric oxide (NO) modulates many behavioral and neuroendocrine responses. Genetic or pharmacological inhibition of the synthetic enzyme that produces NO in neurons evokes elevated and sustained aggression in male mice. Recently, the excessive aggressive and impulsive traits of neuronal NO synthase knockout (nNOS-/-) mice were shown to be caused by reductions in serotonin (5-HT) turnover and deficient 5-HT1A and 5-HT1B receptor function in brain regions regulating emotion. The consistently high… CONTINUE READING


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The use of genetic “knockout” mice in behavioral endocrinology research

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