Interaction of nitric oxide and reactive oxygen species on rat diaphragm contractility.

@article{Lawler2000InteractionON,
  title={Interaction of nitric oxide and reactive oxygen species on rat diaphragm contractility.},
  author={John M Lawler and Zhe-yi Hu},
  journal={Acta physiologica Scandinavica},
  year={2000},
  volume={169 3},
  pages={229-36}
}
Growing evidence indicates that reactive oxygen species (ROS) as well as nitric oxide (NO) have a profound influence on contractile function of skeletal muscle possibly through modulation of excitation-contraction coupling. We hypothesized that if NO and xanthine oxidase (XO) interact at key sites in excitation-contraction coupling, the effects of XO with nitric oxide synthase (NOS) inhibitors and NO donors on contractile function of the unfatigued diaphragm would not be additive. Diaphragm… CONTINUE READING

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