Interaction of neuropeptides and cultured glial (Müller) cells of the chick retina: elevation of intracellular cyclic AMP by vasoactive intestinal peptide and glucagon.

@article{Koh1984InteractionON,
  title={Interaction of neuropeptides and cultured glial (M{\"u}ller) cells of the chick retina: elevation of intracellular cyclic AMP by vasoactive intestinal peptide and glucagon.},
  author={S W Koh and A Kyritsis and Gerald J. Chader},
  journal={Journal of neurochemistry},
  year={1984},
  volume={43 1},
  pages={
          199-203
        }
}
Vasoactive intestinal peptide (VIP) and, to a lesser extent, glucagon were found to increase intracellular cyclic AMP rapidly in cultured glial (Müller) cells of the chick embryo retina. Although VIP elicited higher cyclic AMP accumulation than glucagon at each concentration tested, the half-maximal concentrations were similar, i.e., 6 X 10(-8) M for VIP and 8 X 10(-8) M for glucagon. Secretin had a minimal effect on cyclic AMP accumulation even at a very high (5 X 10(-6) M) concentration… CONTINUE READING

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