Interaction of neuronal nitric-oxide synthase and phosphofructokinase-M.

  title={Interaction of neuronal nitric-oxide synthase and phosphofructokinase-M.},
  author={Bonnie L Firestein and David S. Bredt},
  journal={The Journal of biological chemistry},
  volume={274 15},
Neurons that express neuronal nitric-oxide synthase (nNOS) are resistant to NO-induced neurotoxicity; however, the mechanism by which these neurons are protected is not clear. To identify proteins possibly involved in this process, we performed affinity chromatography with the nNOS PDZ domain, a N-terminal motif that mediates protein interactions. Using this method to fractionate soluble tissue extracts, we identified the muscle isoform of phosphofructokinase (PFK-M) as a protein that binds to… CONTINUE READING


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