Interaction of nateglinide with K(ATP) channel in beta-cells underlies its unique insulinotropic action.

@article{Hu2002InteractionON,
  title={Interaction of nateglinide with K(ATP) channel in beta-cells underlies its unique insulinotropic action.},
  author={Shiling Hu},
  journal={European journal of pharmacology},
  year={2002},
  volume={442 1-2},
  pages={163-71}
}
  • Shiling Hu
  • Published 2002 in European journal of pharmacology
Nateglinide is a novel insulinotropic agent for the treatment of type 2 diabetes. It is a D-phenylalanine derivative, chemically distinct from repaglinide and sulphonylureas (glyburide or glimepiride). Although each agent is known to stimulate insulin release via the signaling cascade initiated by closure of ATP-dependent K+ (K(ATP)) channels in pancreatic beta-cells, the pharmacological effect of nateglinide is reportedly fast-acting, short-lasting, sensitive to ambient glucose and more… CONTINUE READING