Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation

@article{Gu1993InteractionOM,
  title={Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation},
  author={W. Gu and J. Schneider and G. Condorelli and S. Kaushal and V. Mahdavi and B. Nadal-Ginard},
  journal={Cell},
  year={1993},
  volume={72},
  pages={309-324}
}
The experiments reported here document that the tumor suppressor retinoblastoma protein (pRB) plays an important role in the production and maintenance of the terminally differentiated phenotype of muscle cells. We show that pRB inactivation, through either phosphorylation, binding to T antigen, or genetic alteration, inhibits myogenesis. Moreover, inactivation of pRB in terminally differentiated cells allows them to reenter the cell cycle. In addition to its involvement in the myogenic… Expand
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