Interaction of myeloperoxidase with diclofenac. Inhibition of the chlorinating activity of myeloperoxidase by diclofenac and oxidation of diclofenac to dihydroxyazobenzene by myeloperoxidase.

@article{Zuurbier1990InteractionOM,
  title={Interaction of myeloperoxidase with diclofenac. Inhibition of the chlorinating activity of myeloperoxidase by diclofenac and oxidation of diclofenac to dihydroxyazobenzene by myeloperoxidase.},
  author={Karin W.M. Zuurbier and A R Bakkenist and Roel H. Fokkens and Nico M. M. Nibbering and Ron Wever and Anton O. Muijsers},
  journal={Biochemical pharmacology},
  year={1990},
  volume={40 8},
  pages={
          1801-8
        }
}
The chlorinating activity of myeloperoxidase, isolated from human polymorphonuclear neutrophils, was inhibited by the non-steroidal anti-inflammatory drug diclofenac (Voltaren). The concentration of diclofenac needed for 50% inhibition was 20 microM, a value comparable with IC50 values found for other drugs. Diclofenac did not react with HOCl nor with H2O2 but was oxidized in the presence of myeloperoxidase and H2O2 to an orange-coloured unstable product. The rate of oxidation was proportional… CONTINUE READING
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