Interaction of mouse dendritic cells and malaria-infected erythrocytes: uptake, maturation, and antigen presentation.

@article{Ing2006InteractionOM,
  title={Interaction of mouse dendritic cells and malaria-infected erythrocytes: uptake, maturation, and antigen presentation.},
  author={R. van Horssen Ing and M. Garcia Segura and Neeta Thawani and Mifong Tam and Mary M Stevenson},
  journal={Journal of immunology},
  year={2006},
  volume={176 1},
  pages={441-50}
}
Consistent with their seminal role in detecting infection, both mouse bone marrow-derived and splenic CD11c+ dendritic cells (DCs) exhibited higher levels of uptake of Plasmodium chabaudi-parasitized RBCs (pRBCs) than of noninfected RBCs (nRBCs) as determined by our newly developed flow cytometric technique using the dye CFSE to label RBCs before coculture with DCs. To confirm that expression of CFSE by CD11c+ cells following coculture with CFSE-labeled pRBCs represents internalization of pRBC… CONTINUE READING