Interaction of modified cyclodextrins with cytochrome P-450.

  title={Interaction of modified cyclodextrins with cytochrome P-450.},
  author={Minoru Ishikawa and Hidefumi Yoshii and Takeshi Furuta},
  journal={Bioscience, biotechnology, and biochemistry},
  volume={69 1},
The effects of modified cyclodextrins (CDs) hydroxypropyl-beta-CD and methyl-beta-CD were studied in vitro on cDNA-expressed human cytochrome P-450 (CYP) activities (CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4). The modified CDs inhibited the activities of CYP2C19 and CYP3A4 while enhancing CYP2C9 activity by 140 to 176% relative to the control values at lower concentrations. In addition, methyl-beta-CD inhibited CYP1A2 and CYP2D6 at higher concentrations.