Interaction of mitochondrial initiation factor 2 with mitochondrial fMet-tRNA.

  title={Interaction of mitochondrial initiation factor 2 with mitochondrial fMet-tRNA.},
  author={Angela C Spencer and Linda Lucy Spremulli},
  journal={Nucleic acids research},
  volume={32 18},
The mammalian mitochondrial genome contains a single tRNA(Met) gene that gives rise to the initiator and elongator tRNA(Met). It is generally believed that mitochondrial protein synthesis begins with formylmethionyl-tRNA, which indicates that the formylation of mitochondrial Met-tRNA specifies its participation in initiation through its interaction with initiation factor 2 (IF-2). However, recent studies in yeast mitochondria, suggest that formylation is not required for protein synthesis. In… CONTINUE READING


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