Corpus ID: 35076459

Interaction of mithramycin with chromatin.

  title={Interaction of mithramycin with chromatin.},
  author={M. A. Mir and D. Dasgupta},
  journal={Indian journal of biochemistry & biophysics},
  volume={38 1-2},
  • M. A. Mir, D. Dasgupta
  • Published 2001
  • Biology, Medicine
  • Indian journal of biochemistry & biophysics
  • Mithramycin (MTR) is an anti-cancer antibiotic that blocks the macromolecular biosynthesis via reversible interaction with DNA template in the presence of bivalent metal ion such as Mg2+. In absence of DNA, mithramycin forms two types of complexes with Mg2+, complex I (with 1:1 stoichiometry in terms of MTR: Mg2+) and complex II (with 1:2 stoichiometry in terms of MTR: Mg2+). In an eukaryotic system, the drug would interact with chromatin, a protein-DNA complex. We have employed the… CONTINUE READING

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