Interaction of methotrexate with lipotropic factors in rat liver.

@article{Tuma1975InteractionOM,
  title={Interaction of methotrexate with lipotropic factors in rat liver.},
  author={D. Tuma and A. Barak and M. Sorrell},
  journal={Biochemical pharmacology},
  year={1975},
  volume={24 13-14},
  pages={
          1327-31
        }
}
Abstract Methotrexate (MTX), a drug used in cancer chemotherapy and in the treatment of psoriasis, is known to impair DNA and RNA synthesis by antagonizing folate metabolism. A major side-effect of this drug is the formation of a fatty liver and eventual cirrhosis of the liver. Since levels of certain lipotropic substances in the liver are also synthesized de novo by way of folate-dependent 1-carbon metabolism, this study was conducted to determine if the side-effects of MTX may be a… Expand
Effects of choline deficiency and methotrexate treatment upon rat liver.
Effect of methotrexate on homocysteine and other sulfur compounds in tissues of rats fed a normal or a defined, choline-deficient diet
The role of folate, choline, and methionine in carcinogenesis induced by methyl-deficient diets.
Dietary Fats, Lipids, Hormones, and Tumorigenesis
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