Interaction of methadone with substrates of human hepatic cytochrome P450 3A4.

@article{Iribarne1997InteractionOM,
  title={Interaction of methadone with substrates of human hepatic cytochrome P450 3A4.},
  author={Carmen Iribarne and Yvonne Dr{\'e}ano and L G Bardou and Jean Menez and François Berthou},
  journal={Toxicology},
  year={1997},
  volume={117 1},
  pages={
          13-23
        }
}
Methadone, a synthetic drug, is one of the most widely used drugs for opiate dependency treatment. This drug has been demonstrated to be extensively metabolized by cytochrome P450 3A4 in human liver microsomes. Thus, the aim of this in vitro study was to determine if methadone is an inhibitor of other P450s characterized by their specific catalytic activities. Enzymatic activities specific to P450 2E1, P450 1A, P450 2B and P450 2C were not inhibited by methadone. Conversely, nifedipine… CONTINUE READING
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