Interaction of mesoporous silica nanoparticles with human red blood cell membranes: size and surface effects.

@article{Zhao2011InteractionOM,
  title={Interaction of mesoporous silica nanoparticles with human red blood cell membranes: size and surface effects.},
  author={Yannan Zhao and Xiaoxing Sun and Guannan Zhang and Brian G Trewyn and Igor I Slowing and Victor S-Y Lin},
  journal={ACS nano},
  year={2011},
  volume={5 2},
  pages={1366-75}
}
The interactions of mesoporous silica nanoparticles (MSNs) of different particle sizes and surface properties with human red blood cell (RBC) membranes were investigated by membrane filtration, flow cytometry, and various microscopic techniques. Small MCM-41-type MSNs (∼100 nm) were found to adsorb to the surface of RBCs without disturbing the membrane or morphology. In contrast, adsorption of large SBA-15-type MSNs (∼600 nm) to RBCs induced a strong local membrane deformation leading to… CONTINUE READING
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