Interaction of menadione (2-methyl-1,4-naphthoquinone) with glutathione.

  title={Interaction of menadione (2-methyl-1,4-naphthoquinone) with glutathione.},
  author={David O. Ross and Hj{\"o}rdis Thor and Sten Orrenius and Peter Mold{\'e}us},
  journal={Chemico-biological interactions},
  volume={55 1-2},
The interaction of menadione with reduced glutathione (GSH) led to a removal of menadione and formation of menadione-GSH conjugate and glutathione disulfide (GSSG). The changes in thiol level were essentially biphasic with an initial rapid decrease in GSH and appearance of GSSG (less than 1 min) followed by secondary less pronounced changes. The interaction of menadione and GSH caused an oxygen uptake and both superoxide anion radical and hydrogen peroxide were produced during the reaction, the… CONTINUE READING


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