Interaction of memantine and amantadine with agonist-unbound NMDA-receptor channels in acutely isolated rat hippocampal neurons.

@article{Sobolevsky1998InteractionOM,
  title={Interaction of memantine and amantadine with agonist-unbound NMDA-receptor channels in acutely isolated rat hippocampal neurons.},
  author={Alexander I Sobolevsky and Sergey G. Koshelev and Boris I. Khodorov},
  journal={The Journal of physiology},
  year={1998},
  volume={512 ( Pt 1)},
  pages={47-60}
}
1. Using whole-cell patch-clamp techniques, the mechanisms of NMDA channel blockade by amino-adamantane derivatives (AADs) memantine (3, 5-dimethyl-aminoadamantane, MEM) and amantadine (1-aminoadamantane, AM) have been studied in rat hippocampal neurons acutely isolated by the vibrodissociation method. A rapid concentration-jump technique was used to replace superfusing solutions. 2. The aspartate (Asp)-induced channel opening greatly accelerated but was not a prerequisite for the recovery from… CONTINUE READING

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