Interaction of mannose-binding lectin with HIV type 1 is sufficient for virus opsonization but not neutralization.

@article{Ying2004InteractionOM,
  title={Interaction of mannose-binding lectin with HIV type 1 is sufficient for virus opsonization but not neutralization.},
  author={Hongyu Ying and Xin Cheng Ji and Melanie L Hart and Kailash C Gupta and Mohammed Syafiek Saifuddin and Mohammadreza Zariffard and Gregory T. Spear},
  journal={AIDS research and human retroviruses},
  year={2004},
  volume={20 3},
  pages={327-35}
}
Mannose-binding lectin (MBL), a microbe-recognition protein in serum, binds to high mannose glycans on HIV-1 gp120 and has been reported to neutralize the cell line-adapted strain HIV(IIIB). Because HIV primary isolates (PI) are generally more resistant to neutralization by antibodies and considering that PI are produced in primary cells that could alter the number of high mannose glycans on HIV relative to cell lines, we assessed the ability to MBL to neutralize HIV PI. MBL at concentrations… CONTINUE READING

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