Interaction of linear cationic peptides with phospholipid membranes and polymers of sialic acid

  title={Interaction of linear cationic peptides with phospholipid membranes and polymers of sialic acid},
  author={Andrey S. Kuznetsov and Peter V Dubovskii and Olga V Vorontsova and Alexey V. Feofanov and Roman G. Efremov},
  journal={Biochemistry (Moscow)},
Polysialic acid (PSA) is a natural anionic polymer typically occurring on the outer surface of cell membranes. PSA is involved in cell signaling and intermolecular interactions with proteins and peptides. The antimicrobial potential of peptides is usually evaluated in model membranes consisting of lipid bilayers but devoid of either PSA or its analogs. The goal of this work was to investigate the possible effect of PSA on the structure of melittin (Mlt) and latarcins Ltc1K, Ltc2a, and the… CONTINUE READING
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