Interaction of lidocaine and benzocaine in blocking sodium channels

  title={Interaction of lidocaine and benzocaine in blocking sodium channels},
  author={Johann Schmidtmayer and Werner Ulbricht},
  journal={Pfl{\"u}gers Archiv},
1. Single myelinated nerve fibres of the frog,Rana esculenta, were investigated in voltage and current clamp experiments at pH 7.2. 2. Measured with infrequent test pulses, 0.125 mM lidocaine reduced INa to 54%, 0,25 mM benzocaine to 40% and the mixture 0.125 mM lidocaine +0.25 mM benzocaine to 31% of the control. When hyperpolarizing prepulses (V=−40 mV for 15 ms) preceded the test pulses the respective reductions were to 58%, 74% and 55%, i.e. adding benzocaine to lidocaine had little… CONTINUE READING

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Lidocaine-benzocaine interaction at the node of Ranvier

  • J Schmidtmayer, W Ulbricht
  • Pfltigers Arch
  • 1980
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