Interaction of ketamine with μ2 opioid receptors in SH-SY5Y human neuroblastoma cells

@article{Hirota1999InteractionOK,
  title={Interaction of ketamine with μ2 opioid receptors in SH-SY5Y human neuroblastoma cells},
  author={K. Hirota and K. Sikand and D. Lambert},
  journal={Journal of Anesthesia},
  year={1999},
  volume={13},
  pages={107-109}
}
  • K. Hirota, K. Sikand, D. Lambert
  • Published 1999
  • Medicine
  • Journal of Anesthesia
  • AbstractPurpose. Ketamine is known to interact with opioid receptors. However, because this agent does not produce opioid-like respiratory depression, it might not interact with μ2 opioid receptors. Therefore, we have studied the interaction of ketamine with μ2 opioid receptors expressed in SH-SY5Y cells. Methods. SH-SY5Y cells (passage 70–80) were used to obtain ketamine dose-response curves for inhibition of 0.4 nM [3H][d-Ala2,MePhe4,Gly(ol)5] enkephalin (DAMGO) binding to μ2 opioid receptors… CONTINUE READING
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    References

    SHOWING 1-10 OF 11 REFERENCES
    Do nitrous oxide and halothane influence opioid receptor binding in SH-SY5Y human neuroblastoma cells?
    • 11
    Characterisation of mu-opioid receptors on SH-SY5Y cells using naloxonazine and beta-funaltrexamine.
    • 8
    Opiate Receptor Mediation of Ketamine Analgesia
    • 117
    Tyr-D-Arg2-Phe-sarcosine4 activates phospholipase C-coupled mu2-opioid receptors in SH-SY5Y cells.
    • 9
    Pharmacology of Ketamine Isomers in Surgical Patients
    • 355
    Opiate receptor mediation of ketamine analgesia.
    • 120