Interaction of ketamine with μ2 opioid receptors in SH-SY5Y human neuroblastoma cells
@article{Hirota1999InteractionOK, title={Interaction of ketamine with $\mu$2 opioid receptors in SH-SY5Y human neuroblastoma cells}, author={Kazuyoshi Hirota and Kulvinder S. Sikand and David G Lambert}, journal={Journal of Anesthesia}, year={1999}, volume={13}, pages={107-109} }
AbstractPurpose. Ketamine is known to interact with opioid receptors. However, because this agent does not produce opioid-like respiratory depression, it might not interact with μ2 opioid receptors. Therefore, we have studied the interaction of ketamine with μ2 opioid receptors expressed in SH-SY5Y cells.
Methods. SH-SY5Y cells (passage 70–80) were used to obtain ketamine dose-response curves for inhibition of 0.4 nM [3H][d-Ala2,MePhe4,Gly(ol)5] enkephalin (DAMGO) binding to μ2 opioid receptors…
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References
SHOWING 1-10 OF 11 REFERENCES
Do nitrous oxide and halothane influence opioid receptor binding in SH-SY5Y human neuroblastoma cells?
- Biology, MedicineBritish journal of anaesthesia
- 1995
The data suggest that the site of opioid and volatile anaesthetic interaction is not at the opioid receptor, and instead is at the mu receptor selective agonist.
Characterisation of mu-opioid receptors on SH-SY5Y cells using naloxonazine and beta-funaltrexamine.
- BiologyEuropean journal of pharmacology
- 1994
The reversible binding of naloxonazine and the insensitivity of a percentage of the mu-opioid receptor sites to alkylation by beta-funaltrexamine suggests that differences do exist in the mu 2-opIOid receptor population on undifferentiated SH-SY5Y cells.
Properties of the interaction between ketamine and opiate binding sites in vivo and in vitro
- Biology, ChemistryNeuropharmacology
- 1987
Interaction of the chiral forms of ketamine with opioid, phencyclidine, σ and muscarinic receptors
- Biology, Medicine
- 1995
The analgesic effect of ketamine in humans is most probably mediated via phencyclidine receptors, although a kappa effect can not be excluded.
Opiate Receptor Mediation of Ketamine Analgesia
- Biology, ChemistryAnesthesiology
- 1982
In vivo, the authors found that ketamine displaces 3H-etorphine, a potent narcotic, from opiate receptors in regional areas of the mouse brain, especially in the thalamic region, but not in the cortex, suggesting that a significant mechanism of ketamine-induced analgesia is mediated by opiates receptors.
Tyr-D-Arg2-Phe-sarcosine4 activates phospholipase C-coupled mu2-opioid receptors in SH-SY5Y cells.
- Biology, ChemistryEuropean journal of pharmacology
- 1996
Evidence for a supraspinal mechanism in the opioid-mediated antinociceptive effect of ketamine
- Biology, PsychologyBrain Research
- 1991
Stereoselective Interaction of Ketamine with Recombinant [micro sign], [small kappa, Greek], and [small delta, Greek] Opioid Receptors Expressed in Chinese Hamster Ovary Cells
- Biology, Medicine
- 1999
BackgroundThe authors examined the interaction of ketamine with recombinant [micro sign], [small kappa, Greek], and [small delta, Greek] opioid receptors and recombinant orphan opioid receptors…
Pharmacology of Ketamine Isomers in Surgical Patients
- MedicineAnesthesiology
- 1980
Differences in anesthetic potencies, intraoperative effects, analgesia, physical side effects, incidences and types of postanesthetic emergence phenomena, and anesthetic preferences among the optical isomers of ketamine are disclosed.
Opiate receptor mediation of ketamine analgesia.
- Psychology, Biology
- 1982
The authors examined the effects of ketamine in three standard test systems and found that analgesia produced by ketamine can be antagonized by the narcotic antagonist, naloxone.