Interaction of ketamine with μ2 opioid receptors in SH-SY5Y human neuroblastoma cells

  title={Interaction of ketamine with μ2 opioid receptors in SH-SY5Y human neuroblastoma cells},
  author={K. Hirota and K. Sikand and D. Lambert},
  journal={Journal of Anesthesia},
  • K. Hirota, K. Sikand, D. Lambert
  • Published 1999
  • Medicine
  • Journal of Anesthesia
  • AbstractPurpose. Ketamine is known to interact with opioid receptors. However, because this agent does not produce opioid-like respiratory depression, it might not interact with μ2 opioid receptors. Therefore, we have studied the interaction of ketamine with μ2 opioid receptors expressed in SH-SY5Y cells. Methods. SH-SY5Y cells (passage 70–80) were used to obtain ketamine dose-response curves for inhibition of 0.4 nM [3H][d-Ala2,MePhe4,Gly(ol)5] enkephalin (DAMGO) binding to μ2 opioid receptors… CONTINUE READING
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