Interaction of isoquinoline alkaloid palmatine with deoxyribonucleic acids: binding heterogeneity, and conformational and thermodynamic aspects.

Abstract

The binding heterogeneity, conformational aspects, and energetics of the interaction of the cytotoxic plant alkaloid palmatine have been studied with various natural and synthetic DNAs. The alkaloid binds to calf thymus and Escherichia coli DNA that have mixed AT and GC sequences in almost equal proportions with positive cooperativity, while, with… (More)
DOI: 10.1002/cbdv.200890054

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@article{Bhadra2008InteractionOI, title={Interaction of isoquinoline alkaloid palmatine with deoxyribonucleic acids: binding heterogeneity, and conformational and thermodynamic aspects.}, author={Kakali Bhadra and Motilal Maiti and Gopinatha Suresh Kumar}, journal={Chemistry & biodiversity}, year={2008}, volume={5 4}, pages={575-90} }