Interaction of intracellular beta amyloid peptide with chaperone proteins.

  title={Interaction of intracellular beta amyloid peptide with chaperone proteins.},
  author={Virginia Fonte and Wadim Jan Kapulkin and Andrew S. Taft and Amy Fluet and David Friedman and Christopher D Link},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={99 14},
Expression of the human beta amyloid peptide (A beta) in transgenic Caenorhabditis elegans animals can lead to the formation of intracellular immunoreactive deposits as well as the formation of intracellular amyloid. We have used this model to identify proteins that interact with intracellular A beta in vivo. Mass spectrometry analysis of proteins that specifically coimmunoprecipitate with A beta has identified six likely chaperone proteins: two members of the HSP70 family, three alpha B… CONTINUE READING