Interaction of insulin with the renal proximal tubular cell.

  title={Interaction of insulin with the renal proximal tubular cell.},
  author={Marc R. Hammerman},
  journal={The American journal of physiology},
  volume={249 1 Pt 2},
Insulin is known to regulate both metabolic and transport functions in the renal proximal tubule. Insulin present in plasma and in glomerular ultrafiltrate is known to be degraded at this nephron site. This paper summarizes what is known about these processes and about the mechanisms by which the actions of insulin and the degradation of insulin are effected in the proximal tubular epithelial cell. Recent studies have characterized the binding of insulin to specific receptors present in the… CONTINUE READING

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