Interaction of insulin-like growth factor binding protein-3 with latent transforming growth factor-beta binding protein-1

@article{Gui2004InteractionOI,
  title={Interaction of insulin-like growth factor binding protein-3 with latent transforming growth factor-beta binding protein-1},
  author={Yaoting Gui and Liam J. Murphy},
  journal={Molecular and Cellular Biochemistry},
  year={2004},
  volume={250},
  pages={189-195}
}
  • Y. Gui, L. Murphy
  • Published 1 August 2003
  • Biology
  • Molecular and Cellular Biochemistry
Insulin-like growth factor binding protein-3 (IGFBP-3) inhibits the replication and promotes apoptosis in various cell lines in an IGF-independent manner. We utilized a yeast two-hybrid system to identify binding partners for IGFBP-3 in a mouse embryo cDNA library. A partial cDNA encoding mouse latent transforming growth factor beta (TGF-β) binding protein-1 (LTBP-1) was identified. This cDNA encoded a mouse LTBP-1 mRNA fragment corresponding to amino acid residues 1160–1712. Analysis of C… 
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