Interaction of insecticides with mammalian P-glycoprotein and their effect on its transport function.

@article{Sreeramulu2007InteractionOI,
  title={Interaction of insecticides with mammalian P-glycoprotein and their effect on its transport function.},
  author={Kuruba Sreeramulu and Ronghua Liu and Frances Jane Sharom},
  journal={Biochimica et biophysica acta},
  year={2007},
  volume={1768 7},
  pages={1750-7}
}
We studied the effects of four commonly used insecticides (methylparathion, endosulfan, cypermethrin and fenvalerate) on P-glycoprotein isolated from multidrug-resistant cells. All the pesticides stimulated P-glycoprotein ATPase activity, with maximum stimulation of up to 213% in a detergent-solubilized preparation, and up to 227% in reconstituted liposomes… CONTINUE READING