Interaction of influenza virus polymerase with viral RNA in the 'corkscrew' conformation.

@article{Flick1999InteractionOI,
  title={Interaction of influenza virus polymerase with viral RNA in the 'corkscrew' conformation.},
  author={Robert Flick and Gerd Hobom},
  journal={The Journal of general virology},
  year={1999},
  volume={80 ( Pt 10)},
  pages={2565-72}
}
The influenza virus RNA (vRNA) promoter structure is known to consist of the 5'- and 3'-terminal sequences of the RNA, within very narrow boundaries of 16 and 15 nucleotides, respectively. A complete set of single nucleotide substitutions led to the previously proposed model of a binary hooked or 'corkscrew' conformation for the vRNA promoter when it interacts with the viral polymerase. This functional structure is confirmed here with a complete set of complementary double substitutions, of… CONTINUE READING