Interaction of hydrogen peroxide molecules with non-specific DNA recognition sites

  title={Interaction of hydrogen peroxide molecules with non-specific DNA recognition sites},
  author={Dmytro Piatnytskyi and Oleksiy O. Zdorevskyi and Sergey N. Volkov},
  journal={The European Physical Journal D},
Ion beam therapy is one of the most progressive methods in cancer treatment. Studies of the water radiolysis process show that the most long-living species that occur in the medium of a biological cell under the action of ionizing irradiation are hydrogen peroxide ( $$\hbox {H}_2\hbox {O}_2$$ H 2 O 2 ) molecules. But the role of $$\hbox {H}_2\hbox {O}_2$$ H 2 O 2 molecules in the DNA deactivation of cancer cells in ion beam therapy has not been determined yet. In the present paper, the… 



Blocking of DNA specific recognition sites by hydrogen peroxide molecules in the process of ion beam therapy of cancer cells

A new mechanism of the ion irradiation action on living cells, that can be useful for cancer treatment, is formulated using atom-atom potential functions method and quantum-chemical approach based on density functional theory.

Understanding the mechanism of DNA deactivation in ion therapy of cancer cells: hydrogen peroxide action*

Changes in the medium of biological cells under ion beam irradiation has been considered as a possible cause of cell function disruption in the living body. The interaction of hydrogen peroxide, a

The Possibility of Blocking the Process of DNA Base Pairs Opening by Hydrogen Peroxide

The competitive interaction of hydrogen peroxide molecules with nucleic bases in a pair on the different stages of genetic information transfer is studied and Atom-atomic potential functions method is used for the calculations and it is shown, that some configurations of AT and GC complementary pairs are stabilized much better by H$_2$O$-2$ molecule compared to water molecule.

Counterion vibrations in the DNA low-frequency spectra

The calculations of the low-frequency spectra show that for the DNA with metal cations Na+ , K+ , Rb+ and Cs+ the frequency of ion-phosphate vibrations decreases from 174 to 96cm^-1 as the counterion mass increases, proving suggestion about the existence of the ion- phosphate lattice around the DNA double helix.

Simulation of interactions between nucleic acid bases by refined atom-atom potential functions.

Energy of interaction between nitrogen bases of nucleic acid has been calculated as a function of parameters determining the mutual position of two bases. Refined atom-atom potential functions are

Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues.

  • Qi ChenM. Espey M. Levine
  • Biology, Medicine
    Proceedings of the National Academy of Sciences of the United States of America
  • 2005
Human pharmacokinetics data indicate that ascorbate at concentrations achieved only by i.v. administration may be a pro-drug for formation of H(2)O(2), and that blood can be a delivery system of the pro- drug to tissues.

Time- and space-resolved Monte Carlo study of water radiolysis for photon, electron and ion irradiation

The modules of the biophysical Monte Carlo track structure code PARTRAC dealing with the simulation of prechemical and chemical stages have been improved to extend interaction data sets for heavier ions, and good agreement has been found with the calculated time- and LET-dependent yields.

Geometry of the Phosphate Group and Its Interactions with Metal Cations in Crystals and ab Initio Calculations

The phosphate geometry was studied in crystal environment by analyzing 178 crystal structures and in vacuo by ab initio calculations of (di)hydrogen and dimethyl phosphates and a diphosphate model