Interaction of huntingtin fragments with brain membranes--clues to early dysfunction in Huntington's disease.

@article{Suopanki2006InteractionOH,
  title={Interaction of huntingtin fragments with brain membranes--clues to early dysfunction in Huntington's disease.},
  author={Jaana Suopanki and Claudia Goetz and Gudrun Lutsch and J{\"u}rgen Schiller and Phoebe Harjes and Andreas Herrmann and Erich E. Wanker},
  journal={Journal of neurochemistry},
  year={2006},
  volume={96 3},
  pages={870-84}
}
Abstract Huntingtin is a large, multi-domain protein of unknown function in the brain. An abnormally elongated polyglutamine stretch in its N-terminus causes Huntington's disease (HD), a progressive neurodegenerative disorder. Huntingtin has been proposed to play a functional role in membrane trafficking via proteins involved in endo- and exocytosis. Here, we supply evidence for a direct association between huntingtin and membranes. In the brains of R6/2 mice with HD pathology, a 64 kDa N… CONTINUE READING