Interaction of human malignant melanoma tumor spheroids with endothelium and reconstituted basement membrane: modulation by RGDS.

@article{Offner1993InteractionOH,
  title={Interaction of human malignant melanoma tumor spheroids with endothelium and reconstituted basement membrane: modulation by RGDS.},
  author={Felix Albert Offner and I. Bigalke and Johannes Schiefer and Heiner Wirtz and Bernd Klosterhalfen and Hans Feichtinger and C James Kirkpatrick},
  journal={International journal of cancer},
  year={1993},
  volume={54 3},
  pages={506-12}
}
Tumor-cell extravasation involves sequential adhesive interactions with vascular endothelium and the subendothelial basement membrane. We have established a 3-dimensional model in vitro to simulate these events and to elucidate targets of the anti-cell-adhesive synthetic peptide RGDS. Tumor spheroids of the melanoma cell line ST-ML-12 served as models of tumor-cell emboli and were transferred onto human umbilical vein endothelial cells. To imitate the vascular anatomy, the latter were grown on… CONTINUE READING