Interaction of human Ku70 with TRF2

@article{Song2000InteractionOH,
  title={Interaction of human Ku70 with TRF2},
  author={Kyuyoung Song and D Jung and Y Jung and Sang Gon Lee and I Lee},
  journal={FEBS Letters},
  year={2000},
  volume={481}
}
Ku, a heterodimer of 70‐ and 80‐kDa subunits, plays a general role in the metabolism of DNA ends in eukaryotic cells, including double‐strand DNA break repair, V(D)J recombination, and maintenance of telomeres. We have utilized the yeast two‐hybrid system to identify Ku70‐interacting proteins other than Ku80. Two reactive clones were found to encode the dimerization domain of TRF2, a mammalian telomeric protein that binds to duplex TTAGGG repeats at chromosome ends. This interaction was… Expand
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